Impairment of
cell-mediated immunity in cervical cancer (CC) and intraepithelial neoplasia
(CIN) has been reported. In this study, Langerhans cells (LC) subpopulations
were quantitatively evaluated in cervical
tissuesamples obtained from Brazilian patients exhibiting progressive
grades of CIN, (CIN)I (n=3), CINII (n=3) and CINIII (n=3), in addition to three
normal controls.
The precise
number of cervical LC was determined in the entire area of lesioned epithelium
from CIN samples, by performing a morphometric analysis of Langerhans cells
positive for two distinct markers, S100 and Langerin (Lang) detected either by
Immunofluorescence or Immunohistochemistry analysis.
In normal cervix,
a higher density of Langerin+ cells was observed whereas S100+ LC were
predominant in pre-neoplastic lesions samples.
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