Fibroblast growth
factors and their receptors play a key role in cell proliferation, migration
and differentiation. Fibroblast growth factor receptor 2 (FGFR2) is involved
in carcinogenesis and its altered expression has been shown in several
tumors, such as breast, thyroid and pancreatic cancer.
The two isoforms
of FGFR2 gene, FGFR2-IIIb (also known as KGFR) and FGFR2-IIIc have been shown
to exert differential roles in pancreatic cancer.
This review
focuses on the role of FGFR2 signaling in pancreatic adenocarcinoma and the
potential use of FGFR2 tissutal expression as a predictive and/or prognostic
marker.
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