Aging of the Male Germline: Influence of Advanced Male Age on Reproductive Outcome

The rise in life expectancy and the desire to establish a stable career prior to parenthood leads couples to a delayed childbearing. Advanced parental age at the time of pregnancy portrays several risks, with the majority of couples above 35 experiencing reproductive impairments.

While the effect of women’s age on fertility is well known, the influence of paternal age is less understood. Thus, efforts have been made to comprehend the influence of APA on pregnancy upkeep and disease risk for the offspring.

Over the last decades numerous studies aimed to establish the relationship between APA and male fertility potential. It has been found that APA is related to testicular and hormonal alterations, along with a decreased sperm production, quality and DNA integrity.

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Aging of the Male Germline: Influence of Advanced Male Age on Reproductive Outcome

The rise in life expectancy in developed countries, as well as the wish to establish a career prior to parenthood, leads numerous couples to a delayed childbearing. Advanced age at the time of pregnancy portrays clear risks, with a great majority of couples above 35 experiencing reproductive complications.

The effects of women’s age on fertility are well established, being one of the most important factors to consider when addressing fertility issues. Indeed, women over 35 have a compromised fertility, with low oocyte numbers and overall reduced quality.

This biological clock of women’s reproduction capacity restrains fertility after a certain age leading to a decreased capacity to conceive and prolonged time to achieve pregnancy.

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