The rise in life expectancy and the desire to
establish a stable career prior to parenthood leads couples to a delayed
childbearing. Advanced parental age at the time of pregnancy
portrays several risks, with the majority of couples above 35 experiencing
reproductive impairments.
While the effect of women’s age on fertility
is well known, the influence of paternal age is less understood. Thus, efforts
have been made to comprehend the influence of APA on pregnancy upkeep and
disease risk for the offspring.
Over the last decades numerous studies aimed
to establish the relationship between APA and male fertility potential. It has
been found that APA is related to testicular and hormonal alterations, along
with a decreased sperm production, quality and DNA integrity.
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