Intrauterine devices are gaining
prevalence worldwide for family planning purposes because of its long-acting
ature and reversibility. In fact, over 15% of married women were noted to use
intrauterine contraception. Trends demonstrate highest usage in Asian
countries, with at least 50% of Asian females utilizing IUDs for prevention of
pregnancy. Sub-Saharan Africa remains an area where there is a substantial
unmet need for family planning in general.
Two types of IUDs are available:
hormonal and non-hormonal. The most commonly-available hormonal device goes by
the name Mirena, and contains 52 mg of the progestin levonorgestrel (LNG), and
is approved for use over 5 years, although studies have demonstrated efficacy
to 7 years. Initial hormone release rate is 20 mcg/d, which declines to 10
mcg/d at the 5 year mark. Cumulative efficacy is 99.3% over 5 years (which is
as effective as tubal sterilization). The majority of its contraceptive
effect is through thickening of cervical mucous, impedance of sperm
survival and endometrial atrophy, the latter of which explains the improvement
of menstrual flow.

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