Calcium ions play an important
role in almost every aspect of cell communication and sperm function such as,
maturation, motility, and acrosome reaction (AR) in many species. The voltage
gated ion channels are the key part in maintaining the intracellular level of
calcium in sperm cell.
Catspers are novel voltage gated
Ca2+ ion channel located specifically in the principal piece of the sperm tail,
controls the influx
of calcium ions into the spermatozoa, important for sperm motility. The
gene coding for Ca2+ channel are exclusively expressed in the testis.
As the age progresses the sperm
motility detoriates and as Catsper is the gene responsible for maintaining the
sperm motility it becomes important to further elucidate Catsper expression
with the progression of age for which there has been not much studies reported.
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