Calcium ions play an important role in almost every aspect of
cell communication and sperm function such as, maturation, motility, and
acrosome reaction (AR) in many species. The voltage gated ion channels are the
key part in maintaining the intracellular level of calcium in sperm cell.
Catspers are novel voltage gated Ca2+ ion channel located
specifically in the principal piece of the sperm tail, controls the influx of calcium ions
into the spermatozoa,
important for sperm motility. The gene coding for Ca2+ channel are exclusively
expressed in the testis.
As the age progresses the sperm motility detoriates and as
Catsper is the gene responsible for maintaining the sperm motility it becomes
important to further elucidate Catsper expression with the progression of age
for which there has been not much studies reported. Previously, we suggested
that the calcium level drops down with increase in age.
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