Erectile dysfunction (ED) remains one of the most frequent
disturbances of male health with great negative impact on psychological,
behavioral, and social conditions of the affected subject. Moreover, a close
correlation between ED and the risk of cardiovascular diseases has recently
become evident.
The search for safe and efficient approaches to combat and
control ED has been growing steadily.Current pharmacological means target
two major causes of nonandrogen ED revealed so far the impaired signalling from central
nervous system and/or peripherally from penile tissue, to improve local endogenous
metabolic pathways that control the erection process.
The drugs/supplements inducing penile smooth muscle
relaxation are numerous, the best known being prostaglandin E1, NO donors,
phosphodiesterase inhibitors, bioactive peptides, excitatory amino acids, and
antagonists/agonists of neuro-transmitting and other receptors.
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